At least 111 legal pot shops are planning to open across the nation of 37 million people on the first day, according to an Associated Press survey.
River flooding has already prompted water rescues and the National Weather Service warns that heavy rains will continue throughout the week.
"We're just praying to God they find Jayme OK," a relative says.
In Mexico Beach, Florida, Hurricane Michael tossed cars into the canal, snapped trees in half and carved massive craters into U.S. Route 98.
Mary Bono was appointed to the position on Friday to replace Kerry Perry, who resigned in September after just nine months on job.